Applied Bimatics - An Informatics & eHealth Blog

I am a clinician with a passion for informatics. This blog is about my eHealth journey exploring interoperability in Electronic Medical Records (EMR/EHR), Patient Safety, Pharmacovigilance, Data Analytics, Clinical Research and Bioinformatics in a clinical context. Comparing Canadian, Indian and Middle Eastern healthcare systems and services. Join our open facebook group here:


Psoriasis is essentially a proliferative disorder like Lamellar ichthyosis mentioned below. One of the most effective drugs in psoriasis is methotrexate (MTX). Though traditionally we see MTX as an antifolate drug, this does not fully explain its anti psoriatic effect. Various genetic polymorphisms and its effect on MTX cellular pharmacology are described. Can the Bioinformatics study of MTX polymorphisms and its effect on cell division in relation to mutations in Lamellar Ichthyosis (Which are very well characterized unlike Psoriasis) be useful? Post your thoughts here and contact me if you interested in exploring this together.

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.


Bell Raj Eapen
Hamilton, ON