Applied Bimatics - An Informatics & eHealth Blog

I am a clinician with a passion for informatics. This blog is about my eHealth journey exploring interoperability in Electronic Medical Records (EMR/EHR), Patient Safety, Pharmacovigilance, Data Analytics, Clinical Research and Bioinformatics in a clinical context. Comparing Canadian, Indian and Middle Eastern healthcare systems and services. Join our open facebook group here: https://www.facebook.com/groups/clinical.bioinformaticians/


miRNA in Scleroderma


microRNA or miRNA is an ultra short chain RNA produced by eukoryotic cells for epigenetic post transcriptional silencing of mRNA by binding to complementary regions. miRNA-7 downregulation may lead to excessive expression of Type I collagen leading to localised scleroderma and keloids. In comparison with the normal skin tissues, miRNAs were aberrantly expressed in limited cutaneous scleroderma and diffuse cutaneous scleroderma skin tissues as well. Supplementation of the microRNA results in the decrease of collagen expression in scleroderma fibroblasts.

Overview of microRNA processing in animals, fr...
Overview of microRNA processing in animals, from transcription to the formation of the effector complex. Enzymes: Pol II (transcription) and associated proteins Drosha, Pasha (pri-miRNA → pre-miRNA) RAN-GTP, Exportin-5 (export from nucleus) Dicer (pre-miRNA → miRNA) RISC (effector complex) Abbrevations: pri-miRNA = primary microRNA transcript pre-miRNA = precursor microRNA miRNA = microRNA miRNA* = antisense microRNA miRISC = microRNA-induced silencing complex (Photo credit: Wikipedia)

microRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma. (http://www.springerlink.com/content/c7l2t83l21686382/)


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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

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Bell Raj Eapen
Hamilton, ON
Canada