Applied Bimatics - An Informatics & eHealth Blog

I am a clinician with a passion for informatics. This blog is about my eHealth journey exploring interoperability in Electronic Medical Records (EMR/EHR), Patient Safety, Pharmacovigilance, Data Analytics, Clinical Research and Bioinformatics in a clinical context. Comparing Canadian, Indian and Middle Eastern healthcare systems and services. Join our open facebook group here: https://www.facebook.com/groups/clinical.bioinformaticians/


The clinical context

Space-filling model of the chlorpromazine mole...
Space-filling model of the chlorpromazine molecule. X-ray diffraction data from H. S. Yathirajan, M. A. Ashok, B. Narayana Achar and M. Bolte (April 2007). "Chlorpromazinium picrate". Acta. Cryst. E63 (4) : o1795-o1797. DOI:10.1107/S1600536807011555. (Photo credit: Wikipedia)

I recently read an article titled "Structural, phylogenetic and docking studies of D-amino acid oxidase activator (DAOA), a candidate schizophrenia gene". (Open access, link to full text below).

This is a typical example of how over-zealous bioinformatics analysis without a clinical context can churn out garbage. The article after multiple analysis concludes that DAOA interacts with DAO. Well that is why DAOA is named DAO activator. The article also predicts that a predicted ligand of the predicted tertiary structure could be a schizophrenia drug.

If only it were all so simple! If Only....

Ref: http://www.tbiomed.com/content/10/1/3

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

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Bell Raj Eapen
Hamilton, ON
Canada