Applied Bimatics - An Informatics & eHealth Blog

I am a clinician with a passion for informatics. This blog is about my eHealth journey exploring interoperability in Electronic Medical Records (EMR/EHR), Patient Safety, Pharmacovigilance, Data Analytics, Clinical Research and Bioinformatics in a clinical context. Comparing Canadian, Indian and Middle Eastern healthcare systems and services. Join our open facebook group here: https://www.facebook.com/groups/clinical.bioinformaticians/

The information presented here is not intended to diagnose, treat, cure or prevent any disease. Always seek the advice of your own physician or other qualified health care professional. Read full Disclaimer.

Loading .., Please wait!

RELATED LINKS
| Skin Deep - A Dermatology Blog | Hair Loss Blog - A Trichology Blog | Virtual Dermatologist - A Dermatology Expert System | ONTODerm - A Domain Ontology for Dermatology]

Tuesday, February 12, 2013

The clinical context

Space-filling model of the chlorpromazine mole...
Space-filling model of the chlorpromazine molecule. X-ray diffraction data from H. S. Yathirajan, M. A. Ashok, B. Narayana Achar and M. Bolte (April 2007). "Chlorpromazinium picrate". Acta. Cryst. E63 (4) : o1795-o1797. DOI:10.1107/S1600536807011555. (Photo credit: Wikipedia)

I recently read an article titled "Structural, phylogenetic and docking studies of D-amino acid oxidase activator (DAOA), a candidate schizophrenia gene". (Open access, link to full text below).

This is a typical example of how over-zealous bioinformatics analysis without a clinical context can churn out garbage. The article after multiple analysis concludes that DAOA interacts with DAO. Well that is why DAOA is named DAO activator. The article also predicts that a predicted ligand of the predicted tertiary structure could be a schizophrenia drug.

If only it were all so simple! If Only....

Ref: http://www.tbiomed.com/content/10/1/3

Labels: , , , ,

0 Comments:

Post a Comment

All comments, questions and criticisms welcome. Relevant comments with hyperlinks will be accepted. Though this form is not CommentLuv enabled, interesting and useful comments will be acknowledged with DoFollow links in the body of the post. Irrelevant comments and spam will be deleted.

Links to this post:

Create a Link

<< Home

ALL RIGHTS RESERVED GulfDoctor.net