Applied Bimatics - An Informatics & eHealth Blog

I am a clinician with a passion for informatics. This blog is about my eHealth journey exploring interoperability in Electronic Medical Records (EMR/EHR), Patient Safety, Pharmacovigilance, Data Analytics, Clinical Research and Bioinformatics in a clinical context. Comparing Canadian, Indian and Middle Eastern healthcare systems and services. Join our open facebook group here: https://www.facebook.com/groups/clinical.bioinformaticians/


A Biochemical challenge!

Dear Reader

I am back again with a challenge this time. My last challenge got excellent response and I finally published the findings here. This challenge is probably more to do with biochemistry and I hope the Biochemicians facebook group under Prof. PTS would find this problem interesting.

Before I define the problem, please read the posts here to know about the clinical context.

1. The Big Bang Theory

2. Beauty of dark hair.
Molecule Man
Molecule Man (Photo credit: rizkapb)

In brief, Afamelanotide is a peptide drug being developed by Clinuvel pharmaceuticals for tanning. It is a synthetic alpha-MSH analog. (Click here for details)

A new patented molecule claims to have similar mechanism of action. (Click here for details)

The challenge is to find out:

1. How similar is the patented molecule to Afamelanotide?

2. Do you think the new molecule is designed for binding to cysteine rich keratin family in the hair cuticle? Can we improve this binding further by structural alterations?

3. Is the structure optimized for cutaneous penetration? In other words, what is the polarity and other relevant chemical and physical properties of the new molecule?

Please refer to the patented molecule as 'The bang' in your comments.

Thanks

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

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Bell Raj Eapen
Hamilton, ON
Canada