Applied Bimatics - An Informatics & eHealth Blog

I am a clinician with a passion for informatics. This blog is about my eHealth journey exploring interoperability in Electronic Medical Records (EMR/EHR), Patient Safety, Pharmacovigilance, Data Analytics, Clinical Research and Bioinformatics in a clinical context. Comparing Canadian, Indian and Middle Eastern healthcare systems and services. Join our open facebook group here: https://www.facebook.com/groups/clinical.bioinformaticians/


The great anti-ageing mantra


Matrix metalloproteinases (MMPs) are important in dermatology as they are involved in remodelling extracellular matrix (ECM). It is a big family of enzymes, all having a common domain structure with a pro-peptide region, catalytic domain, hinge region and the haemopexin-like C-terminal domain.  They are involved in a variety of biological functions. MMP1 is involved in the premature ageing in smokers.[1] Inhibition of certain MMPs have anti-ageing effect while inhibition of others promote hyperproliferative disorders and scars. However because of the structural similarities, rational design of specific inhibitors are very difficult. Most of the rationally designed MMP inhibitors like  marimastat (BB-2516) and  cipemastat (Ro 32-3555) have performed poorly in clinical studies.

This is a Graph showing the mutual activation ...
This is a Graph showing the mutual activation of matrix metallo-proteinases. (Photo credit: Wikipedia)
This paper [2] proposes a new approach wherein regulatory sites hidden and scattered over different locations on the protein’s surface are targeted instead of the catalytic site using specially designed branched amphiphilic molecules. They have demonstrated that MMP family possess a unique set of such sites making it possible to target specific MMPs without affecting others. If this technology can be successfully developed it may have several applications including many dermatological uses.

References:

1. Lahmann, Christine et al. "Matrix metalloproteinase-1 and skin ageing in smokers." The Lancet 357.9260 (2001): 935-936.

2. Udi, Yael et al. "Unraveling hidden regulatory sites in structurally homologous metalloproteases." Journal of Molecular Biology (2013).


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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

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Bell Raj Eapen
Hamilton, ON
Canada