Applied Bimatics - An Informatics & eHealth Blog

I am a clinician with a passion for informatics. This blog is about my eHealth journey exploring interoperability in Electronic Medical Records (EMR/EHR), Patient Safety, Pharmacovigilance, Data Analytics, Clinical Research and Bioinformatics in a clinical context. Comparing Canadian, Indian and Middle Eastern healthcare systems and services. Join our open facebook group here: https://www.facebook.com/groups/clinical.bioinformaticians/


The clinical context

Space-filling model of the chlorpromazine mole...
Space-filling model of the chlorpromazine molecule. X-ray diffraction data from H. S. Yathirajan, M. A. Ashok, B. Narayana Achar and M. Bolte (April 2007). "Chlorpromazinium picrate". Acta. Cryst. E63 (4) : o1795-o1797. DOI:10.1107/S1600536807011555. (Photo credit: Wikipedia)

I recently read an article titled "Structural, phylogenetic and docking studies of D-amino acid oxidase activator (DAOA), a candidate schizophrenia gene". (Open access, link to full text below).

This is a typical example of how over-zealous bioinformatics analysis without a clinical context can churn out garbage. The article after multiple analysis concludes that DAOA interacts with DAO. Well that is why DAOA is named DAO activator. The article also predicts that a predicted ligand of the predicted tertiary structure could be a schizophrenia drug.

If only it were all so simple! If Only....

Ref: http://www.tbiomed.com/content/10/1/3

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Platelet cryoprecipitate glue

Ref: http://stemcellres.com/content/4/1/1/abstract

The above article grabbed my attention since I have recently evaluated the cosmetic applications of platelet rich plasma (PRP).

From left to right: erythrocyte, thrombocyte, ...
From left to right: erythrocyte, thrombocyte, leukocyte (Photo credit: Wikipedia)
This article explains the promising effects of a platelet cryoprecipitation product rich in growth factors augmenting osteogenesis and bone repair. Does it have any effect on fibroblasts? Can we tweak the technology into an anti-ageing product? Or as I concluded from my PRP evaluation, platelet derived products have an established role in wound/bone repair but not in cosmetic dermatology? Obviously nobody wants a bony skin.

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About Me

As a Dermatologist and Informatician my research mainly involves application of bioinformatics techniques and tools in dermatological conditions. However my research interests are varied and I have publications in areas ranging from artificial intelligence, sequence analysis, systems biology, ontology development, microarray analysis, immunology, computational biology and clinical dermatology. I am also interested in eHealth, Health Informatics and Health Policy.

Address

Bell Raj Eapen
Hamilton, ON
Canada